A patient was diagnosed with infective endocarditis caused by Candida parapsilosis, which further led to inflammation of the right hepatic artery and the formation of pseudoaneurysm, accompanied by intracrania… Read More
Category: General
Recent insights into the pathophysiology and implications for surgery in atherosclerosis
Atherosclerosis is a leading cause of cardiovascular disease. Recent advances in molecular biology have deepened our understanding of its pathogenesis and opened new avenues for surgical intervention.
Comparative analysis of biomechanical properties of grafts and intact tunica albuginea in experiment
Urologiia. 2025 Sep;(4):5-13.
ABSTRACT
INTRODUCTION: Existing treatment methods for Peyronies Disease (PD) aim to restore the normal biomechanical functions of the tunica albuginea (TA); however, current data on biomechanical changes in PD, as well as on the biomechanical properties of native human TA, are extremely limited. The aim of our study was to evaluate the biomechanical properties of intact TA and the materials most commonly used for its replacement.
MATERIALS AND METHODS: Samples of the TA were collected from 9 male cadavers aged 20 to 65 years. Rectangular sections of the TA were excised from the dorsal surface of the corpora cavernosa. Fixation of the specimens in formalin was not performed, as this could affect the biomechanical properties of the tissue. Prepared samples were divided into longitudinal and transverse fragments. Pericardial grafts (allograft from cadaveric pericardium; xenograft from bovine pericardium) were prepared similarly. The obtained tissue fragments were subjected to mechanical testing. All tensile tests were conducted using a single-column universal material testing machine, the TA.XTplus Texture Analyzer (Stable Micro Systems Ltd., UK). Interactive stress-strain curves were used for result analysis. The following parameters were determined: stress, strength, strain, sample thickness. The obtained data were subjected to statistical analysis.
RESULTS: Analysis of the obtained data revealed that the stress and strength of longitudinal fragments of TA were statistically significantly higher (p=0,0004 and p=0,0008; Tukeys test) than those for the transverse fragments. This indicates that human TA is anisotropic. Correlation analysis showed a negative correlation between the patient age and the strength (r=-0,49; p<0,05; Spearmans rank correlation). Additionally, a negative correlation was found between the patients age and the thickness of their tunica albuginea (r=-0,56; p<0,05 according to Spearmans test). When comparing human TA with grafts from bovine and human pericardium, it was found that the strength and thickness calculated for human tunica albuginea were statistically significantly higher (p=0,0001; Tukeys test) than those for the grafts.
CONCLUSIONS: Human and bovine pericardium grafts significantly differ from healthy TA in terms of stress, elastic modulus, strength, and thickness, which may impact the outcomes of surgical treatment for patients with PD.
PMID:40937789
A mediastinal eosinophilic adenoma misdiagnosed as an esophageal stromal tumor: A case report
Eosinophilic adenoma, a benign tumor characterized by eosinophilic cell proliferation, typically arises in endocrine organs such as the thyroid or parathyroid glands. Ectopic parathyroid eosinophilic adenoma i… Read More
Simultaneous pulmonary and intracardiac bone cement embolism after vertebroplasty: a case report and literature review
Pulmonary embolism (PE) is a major contributor to cardiovascular morbidity and mortality. Pulmonary cement embolism (PCE), a rare form of PE, typically arises from bone cement leakage, a recognized complicatio… Read More
Comparative analysis of biomechanical properties of grafts and intact tunica albuginea in experiment
Urologiia. 2025 Sep;(4):5-13.
ABSTRACT
INTRODUCTION: Existing treatment methods for Peyronies Disease (PD) aim to restore the normal biomechanical functions of the tunica albuginea (TA); however, current data on biomechanical changes in PD, as well as on the biomechanical properties of native human TA, are extremely limited. The aim of our study was to evaluate the biomechanical properties of intact TA and the materials most commonly used for its replacement.
MATERIALS AND METHODS: Samples of the TA were collected from 9 male cadavers aged 20 to 65 years. Rectangular sections of the TA were excised from the dorsal surface of the corpora cavernosa. Fixation of the specimens in formalin was not performed, as this could affect the biomechanical properties of the tissue. Prepared samples were divided into longitudinal and transverse fragments. Pericardial grafts (allograft from cadaveric pericardium; xenograft from bovine pericardium) were prepared similarly. The obtained tissue fragments were subjected to mechanical testing. All tensile tests were conducted using a single-column universal material testing machine, the TA.XTplus Texture Analyzer (Stable Micro Systems Ltd., UK). Interactive stress-strain curves were used for result analysis. The following parameters were determined: stress, strength, strain, sample thickness. The obtained data were subjected to statistical analysis.
RESULTS: Analysis of the obtained data revealed that the stress and strength of longitudinal fragments of TA were statistically significantly higher (p=0,0004 and p=0,0008; Tukeys test) than those for the transverse fragments. This indicates that human TA is anisotropic. Correlation analysis showed a negative correlation between the patient age and the strength (r=-0,49; p<0,05; Spearmans rank correlation). Additionally, a negative correlation was found between the patients age and the thickness of their tunica albuginea (r=-0,56; p<0,05 according to Spearmans test). When comparing human TA with grafts from bovine and human pericardium, it was found that the strength and thickness calculated for human tunica albuginea were statistically significantly higher (p=0,0001; Tukeys test) than those for the grafts.
CONCLUSIONS: Human and bovine pericardium grafts significantly differ from healthy TA in terms of stress, elastic modulus, strength, and thickness, which may impact the outcomes of surgical treatment for patients with PD.
PMID:40937789
Prolonged intra-aortic balloon pump support successfully reversed severe pulmonary hypertension prior to heart transplantation
Heart transplantation remains the gold standard for the treatment of end-stage heart failure, but severe pulmonary hypertension (PH) poses a significant challenge due to the increased risk of complications aft… Read More
Global trends and research hotspots in transcatheter valve replacement for aortic regurgitation: a bibliometric and visualized analysis
Transcatheter valve replacement (TAVR) has emerged as a pivotal intervention for aortic regurgitation(AR), garnering significant attention over the past two decades. Despite the proliferation of research in th… Read More
Symptomatic anomalous right coronary artery in mother and daughter, a case report
Anomalous origin of the right coronary artery (AORCA) is a rare, typically asymptomatic congenital cardiac abnormality. Because there are only few reported of cases of familial AORCA, knowledge of its inherita… Read More
Simultaneous pulmonary and intracardiac bone cement embolism after vertebroplasty: a case report and literature review
Pulmonary embolism (PE) is a major contributor to cardiovascular morbidity and mortality. Pulmonary cement embolism (PCE), a rare form of PE, typically arises from bone cement leakage, a recognized complicatio… Read More