Month: June 2026

BMC Oral Health. 2026 May 6. doi: 10.1186/s12903-026-08397-1. Online ahead of print.

ABSTRACT

BACKGROUND: The porcine acellular urinary bladder matrix (AUBM) is a three-dimensional scaffold rich in collagens type I, III, IV, and VI that could be used for guided bone regeneration (GBR). The objective of this study was to compare the physical, mechanical and biological properties of a AUBM with six other collagen membranes of porcine, equine and bovine origin.

METHODS: Seventy membranes were included (n = 10 per group). The properties of AUBM membrane were compared with the other animal collagen membranes available: porcine pericardium (PP), equine pericardium (EP), bovine pericaridium (BP), porcine peritoneum (PPE), equine Achilles tendon (EAT), bovine Achilles tendon (BAT). We analysed physical properties (surface morphology, hydrophilic property, degradation ratio and thermal stability), mechanical properties (tensile strength and dry and wet elongation), and biological properties (cell viability, quantification of type I collagen and osteopontin, Alkaline Phosphatase (ALP) activity and calcium deposition).

RESULTS: AUBM membranes showed a surface morphology (in smooth and rough surfaces) very similar to those of PP, EP, EAT, and BAT. The most hydrophilic membrane was PPE. The AUBM membranes showed a low degradation ratio and thermal stability similar to the other membranes. AUBM membranes had a tensile strength (dry and wet) and elongation (dry) similar to the other membranes. Their elongation was much higher than the rest when wet. AUBM membrane showed good biological properties.

CONCLUSIONS: AUBM membrane showed physical and mechanical properties similar to the other six membranes. However, upon wetting they were the membranes with the highest elongation capacity and showed similar properties to PPE membranes in promoting osteogenesis. AUBM could be an ideal collagen source for the manufacture of membranes for GBR, but further clinical studies are needed.

PMID:42092872 | DOI:10.1186/s12903-026-08397-1

Multimed Man Cardiothorac Surg. 2026 May 6;2026. doi: 10.1510/mmcts.2026.003.

ABSTRACT

Tricuspid regurgitation, associated with poor functional status and reduced survival, is common in patients with rheumatic heart disease after left-sided valve replacement. Although repair is preferred over replacement, surgical repair remains technically challenging. A 60-year-old woman presented with recurrent bilateral leg oedema for 2 years and dizziness with palpitations for 2 months. She had undergone mechanical mitral and aortic valve replacement 18 years earlier for rheumatic heart disease. Echocardiography demonstrated severe central tricuspid regurgitation with preserved prosthetic valve function and atrial arrhythmia. Via median sternotomy and cardiopulmonary bypass, classic rheumatic pathology of the tricuspid valve was identified. Repair consisted of detachment of the anterior and posterior leaflets, augmentation with an annuloplasty-shaped bovine pericardial patch to increase leaflet height and coaptation, and implantation of a partial rigid annuloplasty ring slightly smaller than the patch. Intra-operative echocardiography showed trace residual tricuspid regurgitation. Recovery was uneventful, with early resolution of oedema. Leaflet augmentation combined with partial ring annuloplasty is a simple and reproducible technique that restores early valve competence in complex rheumatic tricuspid regurgitation. Long-term follow-up is required to confirm durability.

PMID:42087840 | DOI:10.1510/mmcts.2026.003

Cardiol Young. 2026 May 14:1-3. doi: 10.1017/S1047951126113067. Online ahead of print.

ABSTRACT

Left ventricular pseudoaneurysm is an exceedingly rare, life-threatening complication following percutaneous balloon aortic valvuloplasty. We report a 1-month-old infant presenting with a large left ventricular pseudoaneurysm after successful valvuloplasty for critical aortic stenosis. Multimodal imaging confirmed the diagnosis. The patient underwent successful surgical resection and bovine pericardial patch repair. This case emphasises the importance of early surgical intervention for favourable outcomes.

PMID:42130344 | DOI:10.1017/S1047951126113067

Int J Biol Macromol. 2026 May;361:151831. doi: 10.1016/j.ijbiomac.2026.151831. Epub 2026 Apr 23.

NO ABSTRACT

PMID:42031605 | DOI:10.1016/j.ijbiomac.2026.151831

Int J Biol Macromol. 2026 May;361:151831. doi: 10.1016/j.ijbiomac.2026.151831. Epub 2026 Apr 23.

NO ABSTRACT

PMID:42031605 | DOI:10.1016/j.ijbiomac.2026.151831

Oper Neurosurg. 2026 Jun 3. doi: 10.1227/ons.0000000000002083. Online ahead of print.

ABSTRACT

BACKGROUND AND OBJECTIVES: Circumferential defects of the dural sleeve of exiting lumbar nerve roots may occur after incidental durotomy, trauma, or deliberate opening of the root cuff during resection of nerve sheath tumors. Standard onlay duraplasty can control cerebrospinal fluid (CSF) leakage but does not restore the tubular dural-epineural conduit. We describe a collagen-matrix cuff technique for root sleeve reconstruction and report our initial institutional experience.

METHODS: This single-center, retrospective case series includes 9 consecutive reconstructions performed between January 2022 and October 2025 for intraoperatively recognized circumferential defects of exiting lumbar nerve root sleeves not amenable to safe primary suturing. The cohort comprised 6 iatrogenic root sleeve defects occurring during elective lumbar procedures (including instrumented and noninstrumented decompressive and/or stabilizing surgeries), 2 post-traumatic cases, and 1 elective tumor case presented as the illustrative case (L3 nerve root ganglioneuroma resection). Clinical records, intraoperative notes, and imaging were reviewed retrospectively. Minimum clinical and MRI follow-up was 6 months for all patients. Adjunctive lumbar drainage was used in one iatrogenic case.

RESULTS: In all cases, a bovine pericardium-derived collagen matrix was prehydrated, tailored, positioned under the root, sutured proximally to the dural margin at the root axilla, and wrapped to form a tubular cuff bridging the dural sac to the epineural segment, with distal reinforcement using fat and fibrin sealant. No patient required reoperation for CSF leak or pseudomeningocele. There were no cases of symptomatic nerve root herniation or new permanent neurological deficit. Radicular symptoms were stable or improved at the last follow-up.

CONCLUSION: Collagen-matrix cuff reconstruction is a simple, anatomically oriented option for circumferential lumbar root sleeve defects when primary closure is not feasible. In this initial single-center experience, the technique provided stable reconstruction without CSF-related complications and may represent a useful adjunct in selected complex root sleeve injuries.

PMID:42233683 | DOI:10.1227/ons.0000000000002083

Ann Thorac Surg Short Rep. 2025 Sep 1;4(1):102-107. doi: 10.1016/j.atssr.2025.08.010. eCollection 2026 Mar.

ABSTRACT

BACKGROUND: Standardized bicuspid aortic valve (BAV) repair makes 2 symmetrical cusps by plicating the fused cusp, which is accompanied by risk of aortic stenosis. Here, the effect of improving cusp mobility by shortening the intercommissural distance (ICD) on increasing the aortic valve area was examined in a BAV model using a pulsatile flow simulator.

METHODS: Six pairs of symmetrical BAV were created in a neo-Valsalva graft with bovine pericardium (free margin length, 26 mm; geometric height, 20 mm), which were incorporated into a pulsation circuit simulator. The ICD was gradually shortened, and the forward flow, leakage flow, pressure gradient, and aortic valve area were measured. The average value of a total of 18 measurements (3 for each model) was examined.

RESULTS: Forward flow remained constant and leakage increased slightly with ICD shortening, but the differences were not statistically significant (P = .17). Peak and mean transvalvular pressure gradient were significantly reduced by ICD shortening (peak: control 26.75 ± 4.33 mm Hg vs 22-mm ICD 23.85 ± 2.91 mm Hg, P < .05; mean: control 17.57 ± 3.59 mmHg vs 20-mm ICD 14.76 ± 2.40 mm Hg, P = .01). Aortic valve area was increased significantly by ICD shortening (control 2.03 ± 0.37 cm² vs 18-mm ICD 2.71 ± 0.47 cm², P <.01).

CONCLUSIONS: With shortening of the ICD, the effect of increasing the aortic valve area and decreasing the pressure gradient was confirmed. Shortening the sinotubular junction diameter (= ICD) is important in aortic valvuloplasty for BAV.

PMID:42027503 | PMC:PMC13100733 | DOI:10.1016/j.atssr.2025.08.010

Ann Thorac Surg Short Rep. 2025 Sep 1;4(1):102-107. doi: 10.1016/j.atssr.2025.08.010. eCollection 2026 Mar.

ABSTRACT

BACKGROUND: Standardized bicuspid aortic valve (BAV) repair makes 2 symmetrical cusps by plicating the fused cusp, which is accompanied by risk of aortic stenosis. Here, the effect of improving cusp mobility by shortening the intercommissural distance (ICD) on increasing the aortic valve area was examined in a BAV model using a pulsatile flow simulator.

METHODS: Six pairs of symmetrical BAV were created in a neo-Valsalva graft with bovine pericardium (free margin length, 26 mm; geometric height, 20 mm), which were incorporated into a pulsation circuit simulator. The ICD was gradually shortened, and the forward flow, leakage flow, pressure gradient, and aortic valve area were measured. The average value of a total of 18 measurements (3 for each model) was examined.

RESULTS: Forward flow remained constant and leakage increased slightly with ICD shortening, but the differences were not statistically significant (P = .17). Peak and mean transvalvular pressure gradient were significantly reduced by ICD shortening (peak: control 26.75 ± 4.33 mm Hg vs 22-mm ICD 23.85 ± 2.91 mm Hg, P < .05; mean: control 17.57 ± 3.59 mmHg vs 20-mm ICD 14.76 ± 2.40 mm Hg, P = .01). Aortic valve area was increased significantly by ICD shortening (control 2.03 ± 0.37 cm² vs 18-mm ICD 2.71 ± 0.47 cm², P <.01).

CONCLUSIONS: With shortening of the ICD, the effect of increasing the aortic valve area and decreasing the pressure gradient was confirmed. Shortening the sinotubular junction diameter (= ICD) is important in aortic valvuloplasty for BAV.

PMID:42027503 | PMC:PMC13100733 | DOI:10.1016/j.atssr.2025.08.010

JTCVS Struct Endovasc. 2025 Mar 4;6:100048. doi: 10.1016/j.xjse.2025.100048. eCollection 2025 Jun.

NO ABSTRACT

PMID:42306055 | PMC:PMC13244763 | DOI:10.1016/j.xjse.2025.100048

Ann Thorac Surg Short Rep. 2025 Sep 1;4(1):102-107. doi: 10.1016/j.atssr.2025.08.010. eCollection 2026 Mar.

ABSTRACT

BACKGROUND: Standardized bicuspid aortic valve (BAV) repair makes 2 symmetrical cusps by plicating the fused cusp, which is accompanied by risk of aortic stenosis. Here, the effect of improving cusp mobility by shortening the intercommissural distance (ICD) on increasing the aortic valve area was examined in a BAV model using a pulsatile flow simulator.

METHODS: Six pairs of symmetrical BAV were created in a neo-Valsalva graft with bovine pericardium (free margin length, 26 mm; geometric height, 20 mm), which were incorporated into a pulsation circuit simulator. The ICD was gradually shortened, and the forward flow, leakage flow, pressure gradient, and aortic valve area were measured. The average value of a total of 18 measurements (3 for each model) was examined.

RESULTS: Forward flow remained constant and leakage increased slightly with ICD shortening, but the differences were not statistically significant (P = .17). Peak and mean transvalvular pressure gradient were significantly reduced by ICD shortening (peak: control 26.75 ± 4.33 mm Hg vs 22-mm ICD 23.85 ± 2.91 mm Hg, P < .05; mean: control 17.57 ± 3.59 mmHg vs 20-mm ICD 14.76 ± 2.40 mm Hg, P = .01). Aortic valve area was increased significantly by ICD shortening (control 2.03 ± 0.37 cm² vs 18-mm ICD 2.71 ± 0.47 cm², P <.01).

CONCLUSIONS: With shortening of the ICD, the effect of increasing the aortic valve area and decreasing the pressure gradient was confirmed. Shortening the sinotubular junction diameter (= ICD) is important in aortic valvuloplasty for BAV.

PMID:42027503 | PMC:PMC13100733 | DOI:10.1016/j.atssr.2025.08.010