Category: General

Sex Med Rev. 2025 Sep 12:qeaf053. doi: 10.1093/sxmrev/qeaf053. Online ahead of print.

ABSTRACT

INTRODUCTION: Peyronie’s disease causes penile curvature and painful erections, potentially impairing quality of life; surgical grafts are employed to correct curvature and restore penetrative sexual function.

OBJECTIVES: This study aimed to summarize the evidence on perioperative and functional outcomes of surgical grafting procedures for Peyronie’s disease.

METHODS: A systematic review was conducted following the PRISMA guidelines. Databases including PubMed, EMBASE, Scopus, Google Scholar, and the Cochrane Library were searched up to April 1, 2023. Eligible studies included retrospective or prospective reports on patients aged 18 years or older treated with various graft materials, including vein, dermal, buccal mucosa, small intestinal submucosa, human cadaveric, and bovine pericardium. Quality was assessed using the JBI Critical Appraisal Checklist. Due to data heterogeneity and a lack of comparative studies, no quantitative synthesis was performed. The systematic review was registered on PROSPERO-CRD42024508997. The review focused on perioperative outcomes, erectile function changes, and complication rates associated with different graft materials.

RESULTS: Out of 521 articles identified from 1933 to 2023, 71 studies involving 2692 patients met the inclusion criteria. Six studies were prospective, and the remainder were retrospective. Quality assessment revealed a high or severely high risk of bias across all included studies. Erectile function worsened in 0%-70% of patients, with complication rates ranging from 0% to 50%. No comparative studies among graft types were identified.

CONCLUSION: Various graft materials offer reliable perioperative and functional outcomes for Peyronie’s disease; however, further comparative studies are essential.

PMID:40966483 | DOI:10.1093/sxmrev/qeaf053

Turk Neurosurg. 2025 Apr 22. doi: 10.5137/1019-5149.JTN.47331-24.3. Online ahead of print.

ABSTRACT

AIM: The advantages of fetal spina bifida repair over postnatal repair were accepted with the publication of the Management of Myelomeningocele Study (MOMS). However, the long-term effects, sequelae, and pathology of fetal surgery are still unclear. Tethered cord recurrence and the need for additional surgery after fetal surgery remain a problem. Inclusion cysts are one reason for reoperation after fetal surgery. Could using a fetoscopic surgical bovine pericardial patch result in fewer inclusion cysts and consequently less granulation tissue?

MATERIAL AND METHODS: This study evaluated the long-term results of nine cases undergoing myelomeningocele repair using fetoscopic surgery, open fetal surgery, or postnatal surgery. We evaluated the occurrence of inclusion cysts and granulation tissue thickness at the surgical site and their effects on the clinical outcome using spinal magnetic resonance imaging (MRI) at the 7-year follow-up.

RESULTS: The granulation tissue at the surgical site was thicker in the prenatal open and postnatal repair groups compared with the fetoscopic repair group. Follow-up spinal MRI revealed an inclusion cyst in one patient who underwent fetoscopic repair versus all of the patients who underwent prenatal open repair and two patients who underwent postnatal myelomeningocele repair. The fetoscopic repair group had better clinical outcomes than the patients who underwent open repair. The patients who underwent prenatal repair had different levels of neurogenic bladder dysfunction. Although none of them needed a urological intervention, their bladder profiles required close follow-up, and their neurological outcomes were obviously better than their urological outcomes.

CONCLUSION: Using a bovine pericardial patch in fetoscopic surgery may protect neural tissue, causing relatively less compression of the neural placode, fewer inclusion cysts, and as a result, less granulation tissue.

PMID:41165389 | DOI:10.5137/1019-5149.JTN.47331-24.3