Month: October 2026

Dent Mater. 2026 Sep 21:S0109-5641(26)00432-X. doi: 10.1016/j.dental.2026.09.010. Online ahead of print.

ABSTRACT

OBJECTIVES: To evaluate the effect of biomimetic apatite mineralization on the physicochemical properties, mechanical behavior, cytocompatibility, and odontogenic differentiation potential of collagen-rich membranes derived from eggshell membrane, equine tendon type I collagen, and bovine pericardium.

METHODS: Membranes were mineralized for 7 days and characterized by X-ray diffraction, scanning electron microscopy with energy-dispersive X-ray spectroscopy, Fourier-transform infrared and Raman spectroscopy, and X-ray photoelectron spectroscopy. Mechanical performance was assessed by microtensile testing, and hDPSC viability by calcein-AM assays up to 21 days. Odontogenic differentiation was evaluated by RT-qPCR for RUNX2, COL-1A1, DSPP, and DMP-1, DMP-1 immunofluorescence, and Alizarin Red S staining and quantification at 21 days. Data were analyzed using one-way or two-way ANOVA followed by Tukey’s post hoc test, as appropriate (α = 0.05).

RESULTS: Biomimetic calcium phosphate coatings formed on all membrane types and enhanced biofunctional performance in a membrane-dependent manner. Mineralization significantly increased tensile strength and toughness in eggshell and pericardium membranes, whereas elastic modulus increased only in pericardium. Equine collagen membranes showed modest, non-significant mechanical changes. Cell viability increased significantly over time, with mineralized membranes promoting greater early viability. Apatite-functionalized membranes increased COL-1A1, DSPP, and DMP-1 expression, while RUNX2 remained comparable among formulations. DMP-1-associated staining was more evident in mineralized membranes, which also showed increased calcium-rich extracellular matrix deposition.

SIGNIFICANCE: Biomimetic apatite mineralization enhanced the mechanical and biological performance of collagen-rich membranes in a substrate-dependent manner. All apatite-functionalized membranes showed favorable properties as bioactive scaffolds for dental pulp regeneration and regenerative endodontic applications.

PMID:42767885 | DOI:10.1016/j.dental.2026.09.010

Dent Mater. 2026 Sep 21:S0109-5641(26)00432-X. doi: 10.1016/j.dental.2026.09.010. Online ahead of print.

ABSTRACT

OBJECTIVES: To evaluate the effect of biomimetic apatite mineralization on the physicochemical properties, mechanical behavior, cytocompatibility, and odontogenic differentiation potential of collagen-rich membranes derived from eggshell membrane, equine tendon type I collagen, and bovine pericardium.

METHODS: Membranes were mineralized for 7 days and characterized by X-ray diffraction, scanning electron microscopy with energy-dispersive X-ray spectroscopy, Fourier-transform infrared and Raman spectroscopy, and X-ray photoelectron spectroscopy. Mechanical performance was assessed by microtensile testing, and hDPSC viability by calcein-AM assays up to 21 days. Odontogenic differentiation was evaluated by RT-qPCR for RUNX2, COL-1A1, DSPP, and DMP-1, DMP-1 immunofluorescence, and Alizarin Red S staining and quantification at 21 days. Data were analyzed using one-way or two-way ANOVA followed by Tukey’s post hoc test, as appropriate (α = 0.05).

RESULTS: Biomimetic calcium phosphate coatings formed on all membrane types and enhanced biofunctional performance in a membrane-dependent manner. Mineralization significantly increased tensile strength and toughness in eggshell and pericardium membranes, whereas elastic modulus increased only in pericardium. Equine collagen membranes showed modest, non-significant mechanical changes. Cell viability increased significantly over time, with mineralized membranes promoting greater early viability. Apatite-functionalized membranes increased COL-1A1, DSPP, and DMP-1 expression, while RUNX2 remained comparable among formulations. DMP-1-associated staining was more evident in mineralized membranes, which also showed increased calcium-rich extracellular matrix deposition.

SIGNIFICANCE: Biomimetic apatite mineralization enhanced the mechanical and biological performance of collagen-rich membranes in a substrate-dependent manner. All apatite-functionalized membranes showed favorable properties as bioactive scaffolds for dental pulp regeneration and regenerative endodontic applications.

PMID:42767885 | DOI:10.1016/j.dental.2026.09.010

Eur J Vasc Endovasc Surg. 2026 Sep 12:S1078-5884(26)00880-4. doi: 10.1016/j.ejvs.2026.09.033. Online ahead of print.

NO ABSTRACT

PMID:42731616 | DOI:10.1016/j.ejvs.2026.09.033

Dent Mater J. 2026 Sep 25;45(5):600-612. doi: 10.4012/dmj.2026-046. Epub 2026 Sep 11.

ABSTRACT

Naturally derived collagen membranes are widely applied in guided bone regeneration (GBR), whereas the implications of different tissue sources remain poorly understood. This study compared bovine pericardium (BP), bovine dermis (BD) and porcine dermis (PD, positive control) collagen membranes in a rat cranial defect model. Results showed that the BP membrane presented the highest type I collagen purity and stable partial degradation over 16 weeks, with superior membrane-adjacent bone formation (20.57-32.02%) and soft tissue healing comparable to the PD membrane. Total bone formation (BV/TV) was comparable across all three groups at 8 and 12 weeks. Despite robust vascularity, the BD membrane induced severe foreign body reactions, limiting tissue integration and local bone formation (<16.87%). Exuberant vascularization may not contribute to tissue regeneration function. Collectively, the BP membrane demonstrated optimal degradation behavior and favorable tissue regeneration performance, supporting its potential as a preferable candidate for GBR applications.

PMID:42732966 | DOI:10.4012/dmj.2026-046

Dent Mater J. 2026 Sep 25;45(5):600-612. doi: 10.4012/dmj.2026-046. Epub 2026 Sep 11.

ABSTRACT

Naturally derived collagen membranes are widely applied in guided bone regeneration (GBR), whereas the implications of different tissue sources remain poorly understood. This study compared bovine pericardium (BP), bovine dermis (BD) and porcine dermis (PD, positive control) collagen membranes in a rat cranial defect model. Results showed that the BP membrane presented the highest type I collagen purity and stable partial degradation over 16 weeks, with superior membrane-adjacent bone formation (20.57-32.02%) and soft tissue healing comparable to the PD membrane. Total bone formation (BV/TV) was comparable across all three groups at 8 and 12 weeks. Despite robust vascularity, the BD membrane induced severe foreign body reactions, limiting tissue integration and local bone formation (<16.87%). Exuberant vascularization may not contribute to tissue regeneration function. Collectively, the BP membrane demonstrated optimal degradation behavior and favorable tissue regeneration performance, supporting its potential as a preferable candidate for GBR applications.

PMID:42732966 | DOI:10.4012/dmj.2026-046

Dent Mater J. 2026 Sep 25;45(5):600-612. doi: 10.4012/dmj.2026-046. Epub 2026 Sep 11.

ABSTRACT

Naturally derived collagen membranes are widely applied in guided bone regeneration (GBR), whereas the implications of different tissue sources remain poorly understood. This study compared bovine pericardium (BP), bovine dermis (BD) and porcine dermis (PD, positive control) collagen membranes in a rat cranial defect model. Results showed that the BP membrane presented the highest type I collagen purity and stable partial degradation over 16 weeks, with superior membrane-adjacent bone formation (20.57-32.02%) and soft tissue healing comparable to the PD membrane. Total bone formation (BV/TV) was comparable across all three groups at 8 and 12 weeks. Despite robust vascularity, the BD membrane induced severe foreign body reactions, limiting tissue integration and local bone formation (<16.87%). Exuberant vascularization may not contribute to tissue regeneration function. Collectively, the BP membrane demonstrated optimal degradation behavior and favorable tissue regeneration performance, supporting its potential as a preferable candidate for GBR applications.

PMID:42732966 | DOI:10.4012/dmj.2026-046

Dent Mater J. 2026 Sep 25;45(5):600-612. doi: 10.4012/dmj.2026-046. Epub 2026 Sep 11.

ABSTRACT

Naturally derived collagen membranes are widely applied in guided bone regeneration (GBR), whereas the implications of different tissue sources remain poorly understood. This study compared bovine pericardium (BP), bovine dermis (BD) and porcine dermis (PD, positive control) collagen membranes in a rat cranial defect model. Results showed that the BP membrane presented the highest type I collagen purity and stable partial degradation over 16 weeks, with superior membrane-adjacent bone formation (20.57-32.02%) and soft tissue healing comparable to the PD membrane. Total bone formation (BV/TV) was comparable across all three groups at 8 and 12 weeks. Despite robust vascularity, the BD membrane induced severe foreign body reactions, limiting tissue integration and local bone formation (<16.87%). Exuberant vascularization may not contribute to tissue regeneration function. Collectively, the BP membrane demonstrated optimal degradation behavior and favorable tissue regeneration performance, supporting its potential as a preferable candidate for GBR applications.

PMID:42732966 | DOI:10.4012/dmj.2026-046

Dent Mater J. 2026 Sep 25;45(5):600-612. doi: 10.4012/dmj.2026-046. Epub 2026 Sep 11.

ABSTRACT

Naturally derived collagen membranes are widely applied in guided bone regeneration (GBR), whereas the implications of different tissue sources remain poorly understood. This study compared bovine pericardium (BP), bovine dermis (BD) and porcine dermis (PD, positive control) collagen membranes in a rat cranial defect model. Results showed that the BP membrane presented the highest type I collagen purity and stable partial degradation over 16 weeks, with superior membrane-adjacent bone formation (20.57-32.02%) and soft tissue healing comparable to the PD membrane. Total bone formation (BV/TV) was comparable across all three groups at 8 and 12 weeks. Despite robust vascularity, the BD membrane induced severe foreign body reactions, limiting tissue integration and local bone formation (<16.87%). Exuberant vascularization may not contribute to tissue regeneration function. Collectively, the BP membrane demonstrated optimal degradation behavior and favorable tissue regeneration performance, supporting its potential as a preferable candidate for GBR applications.

PMID:42732966 | DOI:10.4012/dmj.2026-046

Kyobu Geka. 2026 Jun;79(6):447-450.

ABSTRACT

Mitral annular calcification (MAC) increases the risk of left ventricular rupture during mitral valve replacement (MVR). We report an 81-year-old woman with severe MAC who underwent MVR with preservation of the posterior leaflet and subvalvular apparatus, combined with selective annular debridement using an ultrasonic surgical aspirator and annular reinforcement with a bovine pericardial patch. The valve prosthesis was sewn into place with special attention to suture needle position. Our maneuver enabled safe calcification removal and implantation of an adequately sized prosthesis without left ventricular rupture or paravalvular leakage. Postoperative left ventricular function was well preserved, and the prosthetic valve showed good performance. This technique may reduce the risks of left ventricular rupture and prosthesis-patient mismatch during MVR in patients with severe MAC.

PMID:42722487

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2026 Aug 15;40(8):1304-1313. doi: 10.7507/1002-1892.202603035.

ABSTRACT

OBJECTIVE: To review the research progress and clinical applications of biologically derived materials in scleral reconstruction.

METHODS: A comprehensive review of recent domestic and international literature was conducted to systematically summarize various biologically derived materials, analyzing their therapeutic outcomes and modification strategies in posterior scleral reinforcement (PSR), scleral defect repair, and glaucoma drainage device (GDD) tube coverage.

RESULTS: Biologically derived materials show distinct advantages in different scenarios of scleral reconstruction. In PSR, allogeneic sclera, dura mater, and bovine pericardium can enhance mechanical support of the posterior pole and slow axial elongation; emerging materials such as silk fibroin and gelatin methacrylcyl demonstrate potential in promoting collagen deposition and scleral remodeling. In scleral defect repair, sclera, cornea, amniotic membrane, and collagen matrix can facilitate defect closure, vascularization, and stromal integration. In GDD tube coverage, sclera, cornea, pericardium, and amniotic membrane-umbilical cord tissue can reduce the risk of tube exposure. Overall, individual materials remain limited by mechanical properties, donor availability, or biological activity. Crosslinking modification and composite reinforcement can significantly improve mechanical support and tissue-inductive capacity, promoting the transition from passive repair to active physiological remodeling.

CONCLUSION: Biologically derived materials hold significant value in scleral reconstruction. The development of intelligent and multifunctional composite materials represents the core direction for future research.

PMID:42642202 | PMC:PMC13489736 | DOI:10.7507/1002-1892.202603035