Left atrial appendage cannulation for left ventricular unloading in a patient with ventricular thrombus on extracorporeal life support

Left ventricular unloading is needed in patients on extracorporeal life support (ECLS) with severely impaired left ventricular contractility to avoid stasis and pulmonary congestion, and to promote LV recovery…  Read More

Combined effects of reflexology massage and respiratory relaxation on pain following chest tube removal in heart surgery patients

Removing the chest tube in cardiac patients after surgery is one of the worst experiences of hospitalization in the intensive care units. Various pharmacological and non-pharmacological methods are available t…  Read More

Effect of miR-1285-3p as a diagnostic biomarker for chronic heart failure on vascular endothelial cells

MicroRNAs (miRNAs) are closely related to cardiovascular diseases, including chronic heart failure (CHF). Endothelial dysfunction can lead to heart failure. The purpose of this study was to evaluate the clinic…  Read More

Engineering of a bilayer antibacterial wound dressing from bovine pericardium and electrospun chitosan/PVA/antibiotics for infectious skin wounds management: An in vitro and in vivo study

Int J Biol Macromol. 2024 Dec;282(Pt 5):137055. doi: 10.1016/j.ijbiomac.2024.137055. Epub 2024 Nov 2.

ABSTRACT

Tissue deterioration and post-injury infections are the primary cause of skin diseases. Tissue engineering has developed various synthetic and natural polymers to generate bioactive scaffolds that can closely replicate the natural extracellular matrix (ECM). Decellularized tissues have emerged as a potential solution for reconstructing cutaneous lesions due to their ability to preserve the intricate protein structure and provide essential functional domains for cellular differentiation. In this study, we selected bovine pericardium and subjected it to diverse decellularization methods to optimize ECM preservation. Polyvinyl alcohol (PVA)/chitosan (CS) infused with two clinically important antibiotics (colistin and meropenem) was directly electrospun onto the decellularized bovine pericardium (DBPS) to endow the dual-layer scaffold (DBPS-Abs) an antibacterial property. Both DBPS-Abs and DBPS demonstrated a consistent 3D microstructure with interlinked pore networks, minimal degradation, and robust mechanical stability. The DBPS-Abs group exhibited a potent antibacterial effect against standard and clinical strains of Escherichia coli. Moreover, implanting the constructs into full-thickness skin wounds in mice confirmed enhanced wound regeneration in cases treated with DBPS-Abs compared to other groups, observed over a 7- and 21-day post-implantation period. These findings highlight DBPS-Abs as a superior antibacterial wound dressing, requiring further clinical evaluations.

PMID:39491709 | DOI:10.1016/j.ijbiomac.2024.137055

Aortic lumen repair with glue-felt technique before proximal anastomosis in acute type a aortic dissection surgery

Despite the advances in medicine, aortic dissection remains a cardiac surgery emergency with high mortality and morbidity rates. This study examined the effects of the Glue + Felt technique, which uses biologi…  Read More

Correction to: Histological evaluation of decellularization of freeze dried and chemically treated indigenously prepared bovine pericardium membrane

Cell Tissue Bank. 2024 Dec;25(4):909. doi: 10.1007/s10561-024-10149-w.

NO ABSTRACT

PMID:39476272 | DOI:10.1007/s10561-024-10149-w