Left ventricular unloading is needed in patients on extracorporeal life support (ECLS) with severely impaired left ventricular contractility to avoid stasis and pulmonary congestion, and to promote LV recovery… Read More
Category: General
Analysis of the risk factors of delayed extubation after surgery for Ebstein’s anomaly
In this study, we aimed to screen the risk factors for delayed extubation after surgery for Ebstein’s anomaly (EA), determine the diagnostic cut-off values, and develop a prediction equation to accurately enco… Read More
Combined effects of reflexology massage and respiratory relaxation on pain following chest tube removal in heart surgery patients
Removing the chest tube in cardiac patients after surgery is one of the worst experiences of hospitalization in the intensive care units. Various pharmacological and non-pharmacological methods are available t… Read More
Effect of miR-1285-3p as a diagnostic biomarker for chronic heart failure on vascular endothelial cells
MicroRNAs (miRNAs) are closely related to cardiovascular diseases, including chronic heart failure (CHF). Endothelial dysfunction can lead to heart failure. The purpose of this study was to evaluate the clinic… Read More
A complex case of right heart masses in a leukemia patient: a case report
A patient with acute myeloid leukemia (AML) presented with a cardiac mass of unknown nature. This case underscores the importance of careful monitoring and a multidisciplinary approach in managing and differen… Read More
Engineering of a bilayer antibacterial wound dressing from bovine pericardium and electrospun chitosan/PVA/antibiotics for infectious skin wounds management: An in vitro and in vivo study
Int J Biol Macromol. 2024 Dec;282(Pt 5):137055. doi: 10.1016/j.ijbiomac.2024.137055. Epub 2024 Nov 2.
ABSTRACT
Tissue deterioration and post-injury infections are the primary cause of skin diseases. Tissue engineering has developed various synthetic and natural polymers to generate bioactive scaffolds that can closely replicate the natural extracellular matrix (ECM). Decellularized tissues have emerged as a potential solution for reconstructing cutaneous lesions due to their ability to preserve the intricate protein structure and provide essential functional domains for cellular differentiation. In this study, we selected bovine pericardium and subjected it to diverse decellularization methods to optimize ECM preservation. Polyvinyl alcohol (PVA)/chitosan (CS) infused with two clinically important antibiotics (colistin and meropenem) was directly electrospun onto the decellularized bovine pericardium (DBPS) to endow the dual-layer scaffold (DBPS-Abs) an antibacterial property. Both DBPS-Abs and DBPS demonstrated a consistent 3D microstructure with interlinked pore networks, minimal degradation, and robust mechanical stability. The DBPS-Abs group exhibited a potent antibacterial effect against standard and clinical strains of Escherichia coli. Moreover, implanting the constructs into full-thickness skin wounds in mice confirmed enhanced wound regeneration in cases treated with DBPS-Abs compared to other groups, observed over a 7- and 21-day post-implantation period. These findings highlight DBPS-Abs as a superior antibacterial wound dressing, requiring further clinical evaluations.
PMID:39491709 | DOI:10.1016/j.ijbiomac.2024.137055
Aortic lumen repair with glue-felt technique before proximal anastomosis in acute type a aortic dissection surgery
Despite the advances in medicine, aortic dissection remains a cardiac surgery emergency with high mortality and morbidity rates. This study examined the effects of the Glue + Felt technique, which uses biologi… Read More
Anomalous drainage of lingular vein into left inferior pulmonary vein during thoracoscopic lung cancer surgery
The intricate anatomical variations in lung structure often perplex thoracic surgeons, and the accurate identification of these variations is closely associated with favorable surgical outcomes.
Correction to: Histological evaluation of decellularization of freeze dried and chemically treated indigenously prepared bovine pericardium membrane
Cell Tissue Bank. 2024 Dec;25(4):909. doi: 10.1007/s10561-024-10149-w.
NO ABSTRACT
PMID:39476272 | DOI:10.1007/s10561-024-10149-w
Combined simulation and ex vivo assessment of free-edge length in bicuspidization repair for congenital aortic valve disease
JTCVS Open. 2024 Sep 17;22:395-404. doi: 10.1016/j.xjon.2024.09.008. eCollection 2024 Dec.
ABSTRACT
OBJECTIVE: The study objective was to investigate the effect of free-edge length on valve performance in bicuspidization repair of congenitally diseased aortic valves.
METHODS: In addition to a constructed unicuspid aortic valve disease model, 3 representative groups-free-edge length to aortic diameter ratio 1.2, 1.57, and 1.8-were replicated in explanted porcine aortic roots (n = 3) by adjusting native free-edge length with bovine pericardium. Each group was run on a validated ex vivo univentricular system under physiological parameters for 20 cycles. All groups were tested within the same aortic root to minimize inter-root differences. Outcomes included transvalvular gradient, regurgitation fraction, and orifice area. Linear mixed effects model and pairwise comparisons were used to compare outcomes across groups.
RESULTS: The diseased control group had a mean transvalvular gradient of 28.3 ± 5.5 mm Hg, regurgitation fraction of 29.6% ± 8.0%, and orifice area of 1.03 ± 0.15 cm2. In ex vivo analysis, all repair groups had improved regurgitation and transvalvular gradient compared with the diseased control group (P < .001). Free-edge length to aortic diameter of 1.8 had the highest amount of regurgitation among the repair groups (P < .001) and 1.57 the least (P < .001). Free-edge length to aortic diameter of 1.57 also exhibited the lowest mean gradient (P < .001) and the largest orifice area (P < .001).
CONCLUSIONS: Free-edge length to aortic diameter ratio significantly impacts valve function in bicuspidization repair of congenitally diseased aortic valves. As the ratio departs from 1.57 in either direction, effective orifice area decreases and both transvalvular gradient and regurgitation fraction increase.
PMID:39780804 | PMC:PMC11704580 | DOI:10.1016/j.xjon.2024.09.008