The safety and efficacy of prophylactic corticosteroid administration during the perioperative period of cardiac surgery have undergone extensive and comprehensive examination. In this study, we conducted a bi… Read More
Category: General
Comparison of outcomes post Cor-Knot versus Manual tying in valve surgery: our 8-year analysis of over 1000 patients
In the era of minimally invasive valve surgery (MIVS), automated titanium fasteners such as Cor Knot®, have reduced aortic-cross clamp (AXC) and cardiopulmonary bypass (CPB) times to improve survival outcomes… Read More.
Knowledge domains and hotspots in corticosteroid use for cardiac surgery: a 23-Year bibliometric and visualized analysis
The safety and efficacy of prophylactic corticosteroid administration during the perioperative period of cardiac surgery have undergone extensive and comprehensive examination. In this study, we conducted a bi… Read More
Pseudoaneurysm formation at the right ventricular anastomosis of a pulmonary homograft following tetralogy of Fallot repair: a rare late complication
We report a 7-year-old boy with tetralogy of Fallot who developed a right ventricular pseudoaneurysm one year after right ventricular outflow tract reconstruction with a 17 mm pulmonary homograft. Urgent reoperation revealed proximal homograft dehiscence. Repair was performed using an Invengenx® pericardial patch. This rare complication highlights the importance of long-term surveillance following homograft implantation in congenital heart surgery.
Öztürker K, Tunçer E, Köksal AU. Pseudoaneurysm formation at the right ventricular anastomosis of a pulmonary homograft following tetralogy of Fallot repair: a rare late complication. Cardiology in the Young. Published online 2025:1-3. doi:10.1017/S1047951125101467
Animal model of a bovine pericardial patch for thoracoabdominal aortic aneurysms: step by step
J Vasc Bras. 2025 Jun 13;24:e20240182. doi: 10.1590/1677-5449.202401822. eCollection 2025.
ABSTRACT
BACKGROUND: The treatment of thoracoabdominal aortic aneurysms (TAA) has advanced. Understanding the pathophysiology and surgical approaches to this disease is essential for best therapeutic performance.
OBJECTIVES: We aimed to improve previously described methods for creating thoracoabdominal aortic aneurysms in a porcine animal model, reducing surgical procedure time and specimen mortality.
METHODS: A total of 18 swine underwent a surgical procedure to create a TAA. An autologous peritoneal patch was used to create the aneurysm in 2 animals, and a bovine pericardial patch was used in the other 16. The animals were followed up postoperatively, and the aneurysm sac was reexamined after 4 weeks. The animals that did not die in the post-operative period were euthanized according to institutional recommendations.
RESULTS: All of the animals underwent laparotomy with retroperitoneal access. Two received an autologous peritoneal patch and 16 received a bovine pericardial patch. Three animals underwent single suprarenal clamping, while 15 underwent sequential clamping. There were no differences in operative time (p=0.207) or total clamping time (p=0.276) between groups. There was a higher mortality rate after 4 weeks in animals that received single clamping (100%) than sequential clamping (26.7%) (p=0.0017).
CONCLUSIONS: The experimental model of TAA using a bovine pericardial patch and a sequential clamping technique provided a stable and reliable platform that remains stable and patent for up to 4 weeks. This model can be extremely valuable for assessing new endovascular therapy options in living organisms.
PMID:40557052 | PMC:PMC12186686 | DOI:10.1590/1677-5449.202401822
NSUN2 inhibits NCOA4 expression to alleviate ferroptosis and inflammation in sepsis-induced myocardial injury in a m5C manner
Sepsis-induced myocardial injury (SIMI) leads to high morbidity and mortality. The 5-methylcytosine (m5C) RNA methyltransferase NOL1/NOP2/SUN domain (NSUN)2 is a therapeutic target for many diseases. The purpose … Read More
NSUN2 inhibits NCOA4 expression to alleviate ferroptosis and inflammation in sepsis-induced myocardial injury in a m5C manner
Sepsis-induced myocardial injury (SIMI) leads to high morbidity and mortality. The 5-methylcytosine (m5C) RNA methyltransferase NOL1/NOP2/SUN domain (NSUN)2 is a therapeutic target for many diseases. The purpose … Read More
A retrospective observational study of tetralogy of fallot with pulmonary atresia and ductal-dependent pulmonary circulation focusing on the staged transannular patch procedure: a single-center study
Management of pulmonary atresia with ventricular septal defect and ductal-dependent pulmonary circulation (PA/VSD/PDA) varies according to pulmonary artery morphology and institutional surgical strategy. We ad… Read More
NSUN2 inhibits NCOA4 expression to alleviate ferroptosis and inflammation in sepsis-induced myocardial injury in a m5C manner
Sepsis-induced myocardial injury (SIMI) leads to high morbidity and mortality. The 5-methylcytosine (m5C) RNA methyltransferase NOL1/NOP2/SUN domain (NSUN)2 is a therapeutic target for many diseases. The purpose … Read More
Why are soft collagenous tissues so tough?
Sci Adv. 2025 Jun 20;11(25):eadw0808. doi: 10.1126/sciadv.adw0808. Epub 2025 Jun 18.
ABSTRACT
Bovine pericardium is the tissue of choice for replacing heart valves of human patients in minimally invasive surgery. The tissue has an extraordinarily high toughness of ~100 kilojoules per square meter. Here, we investigate the origin of the toughness through mechanical tests and microscopic observations. In the tissue, crimped, long, strong collagen fibers are embedded in a soft matrix. As a crack grows in the matrix, the fibers decrimp, reorient, slip, and bridge the crack. These microscopic processes enable the fibers to transmit high tension over a long distance. Using two types of experiments, we measure the bridging traction as a function of crack separation, σ(δ). The peak traction is σ0 ~ 60 megapascals. The maximum separation is δ0 ~ 6 millimeters, two to four orders of magnitude higher than that of hard tissues. Both the high traction and large separation of the bovine pericardium contribute to its high toughness.
PMID:40532007 | PMC:PMC12175909 | DOI:10.1126/sciadv.adw0808