Month: March 2026

Sci Rep. 2026 Feb 4;16(1):7315. doi: 10.1038/s41598-026-35729-6.

ABSTRACT

As the demand for aortic valve prostheses grows, optimizing their mechanical performance and durability is essential. While mechanical valves offer longevity, their need for lifelong anticoagulation limits their use, making bioprosthetic valves a preferred alternative. However, bioprosthetic valves made from bovine pericardium face durability challenges due to structural degradation. Given that valve functionality is heavily influenced by the collagen architecture and mechanical properties of the tissue, selecting an optimal replacement is essential. This study evaluates treated ovine aortic valves as an alternative material, comparing their mechanical behavior to native human valves. Tensile tests showed an elastic modulus of 20.17 MPa for treated ovine leaflets, while human leaflets ranged from 6.15 MPa to 28.10 MPa. Stress relaxation tests indicated a 41% stress reduction in treated ovine valves compared to 21% in human valves after 300 s, suggesting greater viscoelasticity. Finite element analysis revealed lower peak systolic stress in treated ovine valves (0.36 MPa vs. 0.72 MPa in human valves), with stress distributions aligning with clinically observed degradation sites. These findings highlight ovine tissue’s potential for improved durability and flexibility, making it a strong candidate for next-generation bioprosthetic heart valves.

PMID:41639159 | PMC:PMC12923552 | DOI:10.1038/s41598-026-35729-6

Sci Rep. 2026 Feb 4;16(1):7315. doi: 10.1038/s41598-026-35729-6.

ABSTRACT

As the demand for aortic valve prostheses grows, optimizing their mechanical performance and durability is essential. While mechanical valves offer longevity, their need for lifelong anticoagulation limits their use, making bioprosthetic valves a preferred alternative. However, bioprosthetic valves made from bovine pericardium face durability challenges due to structural degradation. Given that valve functionality is heavily influenced by the collagen architecture and mechanical properties of the tissue, selecting an optimal replacement is essential. This study evaluates treated ovine aortic valves as an alternative material, comparing their mechanical behavior to native human valves. Tensile tests showed an elastic modulus of 20.17 MPa for treated ovine leaflets, while human leaflets ranged from 6.15 MPa to 28.10 MPa. Stress relaxation tests indicated a 41% stress reduction in treated ovine valves compared to 21% in human valves after 300 s, suggesting greater viscoelasticity. Finite element analysis revealed lower peak systolic stress in treated ovine valves (0.36 MPa vs. 0.72 MPa in human valves), with stress distributions aligning with clinically observed degradation sites. These findings highlight ovine tissue’s potential for improved durability and flexibility, making it a strong candidate for next-generation bioprosthetic heart valves.

PMID:41639159 | PMC:PMC12923552 | DOI:10.1038/s41598-026-35729-6

Rev Med Liege. 2025 Dec;80(12):770-775.

ABSTRACT

Prosthetic vascular infections are rare, occurring in less than 3 % of cases. If left untreated within the required timeframe, serious complications such septic shock and anastomotic rupture with hemorrhage may occur and lead to the patient’s death. Targeted and prolonged intravenous or oral antibiotic therapy is necessary but insufficient without surgical revision and removal of the infected prosthetic material. Once the infected prosthetic material is removed, blood continuity must be restored to ensure downstream vascularization and avoid amputation. There are two types of repair: extra-anatomical and in situ reconstructions. For the latter, it is ideal to avoid using prosthetic material. The solutions described in the literature are most often autologous venous grafts and cryopreserved arterial allografts. These are not always available. An alternative is to use a bovine pericardial patch, shaping it into a tube on the table with a longitudinal suture. We report a case of an infected common femoral artery prosthesis replaced with a pericardial patch and covered with the sartorius muscle.

PMID:41392629