Month: February 2024

J Mater Chem B. 2024 Jan 31;12(5):1244-1256. doi: 10.1039/d3tb01661g.

ABSTRACT

Implanting physical barrier materials to separate wounds from their surroundings is a promising strategy for preventing postoperative adhesions. Herein, we develop a material that switches from an anti-adhesive surface to an adhesive surface, preventing adhesion in the early stage of transplantation and then promoting recellularization. In this study, 2-arm, 4-arm, and 8-arm poly(ethylene glycol) succinimidyl glutarate (2-, 4-, 8-arm PEG-NHS) were used to modify the surface of decellularized porcine and bovine pericardium. The number of free amines on the surface of each material significantly decreased following modification regardless of the reaction molar ratio of NH₂ and NHS, the number of PEG molecule branches, and the animal species of the decellularized tissue. The structure and mechanical properties of the pericardium were maintained after modification with PEG molecules. The time taken for the PEG molecules to detach through hydrolysis of the ester bonds differed between the samples, which resulted in different cell repulsion periods. By adjusting the reaction molar ratio, the number of PEG molecule branches, and the animal species of the decellularized pericardium, the duration of cell repulsion can be controlled and is expected to provide an anti-adhesion material for a variety of surgical procedures.

PMID:38168715 | DOI:10.1039/d3tb01661g

Cureus. 2023 Nov 25;15(11):e49381. doi: 10.7759/cureus.49381. eCollection 2023 Nov.

ABSTRACT

A 72-year-old man presented with intermittent claudication and a foot ulcer. Computed tomography revealed severe calcification and occlusion of the left femoral artery and calcification and stenosis from the superficial femoral artery to the popliteal artery. Thromboendarterectomy (TEA) and anterior reconstruction of the femoral artery with a bovine pericardium patch were performed. We sutured the great saphenous vein on the bovine pericardium patch for bypass inflow after creating an anastomosis hole with a puncher and performed an in situ femorotibial bypass. This technique helped us achieve a smooth and clean anastomosis. In situ vein graft anastomosis might be difficult on severely atherosclerotic femoral artery after TEA and difficult anastomosis increases the risk of bypass occlusion. Anastomosis on the bovine pericardium patch for bypass inflow might ensure smooth and clean anastomosis in patients with severe atherosclerosis of the femoral artery.

PMID:38024018 | PMC:PMC10676049 | DOI:10.7759/cureus.49381

J Mater Chem B. 2024 Jan 31;12(5):1244-1256. doi: 10.1039/d3tb01661g.

ABSTRACT

Implanting physical barrier materials to separate wounds from their surroundings is a promising strategy for preventing postoperative adhesions. Herein, we develop a material that switches from an anti-adhesive surface to an adhesive surface, preventing adhesion in the early stage of transplantation and then promoting recellularization. In this study, 2-arm, 4-arm, and 8-arm poly(ethylene glycol) succinimidyl glutarate (2-, 4-, 8-arm PEG-NHS) were used to modify the surface of decellularized porcine and bovine pericardium. The number of free amines on the surface of each material significantly decreased following modification regardless of the reaction molar ratio of NH₂ and NHS, the number of PEG molecule branches, and the animal species of the decellularized tissue. The structure and mechanical properties of the pericardium were maintained after modification with PEG molecules. The time taken for the PEG molecules to detach through hydrolysis of the ester bonds differed between the samples, which resulted in different cell repulsion periods. By adjusting the reaction molar ratio, the number of PEG molecule branches, and the animal species of the decellularized pericardium, the duration of cell repulsion can be controlled and is expected to provide an anti-adhesion material for a variety of surgical procedures.

PMID:38168715 | DOI:10.1039/d3tb01661g