Category: Tisgenx

Engineered heterografts like bovine pericardial tissue patches are often fashioned into conduits for repairs of complex congenital cardiac defects such as truncus arteriosus (BPTP). Choosing the right graft that has suitable mechanical properties, durability, antigenicity and availability in the right size and shape is a difficult task. We report our initial experience with the new Invengenx^® BPTP that is crosslinked using proprietary fixation methodology called elixP™ in a 6-month-old patient with a type 2 TA on whom we performed a truncus repair, closure of ventricular septal defect (VSD) and right ventricular outflow tract (RVOT) reconstruction. A size XM-12 (2×9 cm) Invengenx^® BPTP was hand-sewn to prepare a conduit. Distal anastomosis was done between the conduit and the PA confluence. The conduit could be hand-sewn with ease, had optimal thickness and strength and showed good performance as seen on post-operative echocardiography.

Shah, P., T. Dudde, S. Kamath, K. Surya, K. V. Bilgi, and R. Kupumbati. “Initial Experience of Using the Invengenx® Bovine Pericardial Tissue Patch for Common Arterial Trunk Repair”. International Journal of Research in Medical Sciences, vol. 12, no. 7, June 2024, pp. 2722-3, doi:10.18203/2320-6012.ijrms20241941.

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Complete congenital Atrio-Ventricular (AV) septal defect repair is a complex technique and can be performed as a single patch, modified single patch or a double patch technique. In addition, reconstructive surgeries make it more challenging as the native pericardium available for the repair is limited and of poor quality. Thus, the use of engineered bovine pericardium can help in the reconstruction of large AV canal defects. We used the Invengenx® patch for the repair of a complete AV canal defect and Pulmonary Artery (PA) plasty in a 20 month old female child with a previous PA banding. The patch had good flexibility, mechanical strength, suturability and there were no complications such as thrombosis or infection on follow up.

Reconstructive surgery in congenital cardiac anomalies is fraught with challenges due to surgical complexities and the limited availability of native pericardium for performing the repair of large defects. We used the Invengenx® bovine pericardial tissue patch for the repair of a complete AVSD (post-pulmonary artery banding) and found the patch to be suitable for the re-do procedure and noted uniform thickness, good flexibility, mechanical strength, suture retention and no infection or thrombosis.

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Ventricular septal defects (VSDs) are a prevalent congenital heart anomaly demanding safe and lasting interventions. This paper explores the application of Invengenx® bovine pericardial patch (Tisgenx, Irvine, California), a promising biomaterial, in VSD repair. We present two case studies: a seven-month-old infant and a three-year-old child undergoing VSD closure using autologous and bovine pericardial patches, respectively.

Bhende, Vishal V et al. “Beyond Synthetics: Promising Outcomes With the Invengenx® Bovine Pericardial Patch for Ventricular Septal Defect Repair in a Young Pediatric Population.” Cureus vol. 16,3 e55530. 4 Mar. 2024, doi:10.7759/cureus.55530

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Complex congenital heart diseases (CHDs), such as the tetralogy of Fallot (TOF), often warrant reconstruction and augmentation of the right ventricular outflow tract (RVOT). This procedure requires the use of both synthetic and natural materials. However, finding the ideal material for tissue implants can be challenging. Biological materials often face issues such as tissue degeneration, calcium deposition, antigenicity, rejection, shrinkage, and fibrosis. These issues can lead to complications such as stenosis and insufficiency, potentially requiring early reoperations. In light of this, this study aimed to investigate the effectiveness of the Invengenx® bovine patch for RVOT reconstruction and augmentation.

Bhende, Vishal V et al. “The Utility of Invengenx® Bovine Patch for Right Ventricular Outflow Tract (RVOT) Reconstruction and Augmentation in the Surgical Management of Tetralogy of Fallot (TOF): A Contemporary Study and Review of the Literature.” Cureus vol. 15,10 e46882. 12 Oct. 2023, doi:10.7759/cureus.46882

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