To evaluate the impact of preoperative pleural effusion on the ultrasound visualization of the paravertebral space (PVS), thoracic paravertebral nerve block administered by anesthesiologists, and to investigat… Read More
Category: General
Network pharmacology-based prediction and molecular docking-based strategy to investigate the potential mechanism of Leonurus japonicus Houtt. Against myocardial ischemia reperfusion injury
Leonurus japonicus Houtt. (LJH) has multiple pharmacological effects.
GPER1-mediated suppression of acute cellular rejection in murine cervical heart transplantation by estradiol
This study aimed to investigate the inhibitory effect of estradiol (E2) on acute cellular rejection following murine cervical heart transplantation and the role of G protein-coupled estrogen receptor 1 (GPER1).
Prognostic impact of surgery on thymic malignancies with concurrent or previous extrathymic malignancies: a retrospective analysis from 1998 to 2021
There is limited research on the impact of surgery on the cancer-specific survival (CSS) of patients with malignant thymoma and concurrent or previous extrathymic malignancies (PMTEMs). This retrospective anal… Read More
Network pharmacology-based prediction and molecular docking-based strategy to investigate the potential mechanism of Leonurus japonicus Houtt. Against myocardial ischemia reperfusion injury
Leonurus japonicus Houtt. (LJH) has multiple pharmacological effects.
Construction and validation of a nomogram model for predicting the risk of recurrence in patients with lower extremity arteriosclerosis obliterans after surgical intervention
To explore and analyze the risk factors for recurrence in patients with lower extremity arteriosclerosis obliterans (ASO) after surgical intervention and to construct and validate a nomogram prediction model.
Surgical management of type A aortic dissection during the second trimester: a case report
Acute aortic dissection during pregnancy is a relatively rare but often life-threatening conditio. A previous study showed that the overall incidence of the disease was about 4 in 1 million women aged 15–45 ye… Read More
Anomalous origin of the right coronary artery with severe stenosis of the left coronary artery orifice: a case study
Anomalous aortic origin of the coronary artery (AAOCA) represents a form of congenital heart disease. Several primary types of anomalous origin of the coronary artery (AOCA) exist. Patients with certain AOCA t… Read More
New Wrapping Biomaterial Alternatives for Fascia in Diced Cartilage Grafts: A Comparative Study on Viability and Stability
Aesthetic Plast Surg. 2025 Feb 28. doi: 10.1007/s00266-025-04770-7. Online ahead of print.
ABSTRACT
OBJECTIVE: The aim of this in vivo study is to compare cartilage viability within diced cartilage grafts from the perspective of three wrapping biomaterials Group A acellular dermal matrix (FlexHD®), Group T bovine pericardium (Tutopatch®), and Group F allogeneic human fascia for a possible implementation in the clinical use.
MATERIALS AND METHODS: This in vivo study was conducted on 5 SCID (Severe Combined Immunodeficiency)/Gamma Mice with a duration of eight weeks. The cartilage within composite grafts were obtained from the remaining cartilage following secondary rhinoplasty performed on a single donor. Diced cartilage grafts were wrapped separately with acellular dermal matrix (ADM), bovine pericardium, and fascia to form three groups. A total of five mice were utilized in all three experimental groups, with a total of 15 experimental materials being examined. One composite graft from each group was implanted into the backs of the mice. The effects of the biomaterials on the viability and stability of the composite grafts were evaluated. Viability was evaluated through LIVE/DEAD cell analysis and histopathological examinations. Stability was assessed by comparing weight and volume changes of the grafts, measured using a precision balance and computed tomography, respectively.
RESULTS: A significant increase in weight was found in the fascia group after implantation (p < 0.05). In the ADM (Group A) and bovine pericardium (Group T), no statistically significant weight change was observed (p > 0.05). A significant increase in volume was found in the ADM (Group A) group after implantation (p < 0.05). Flow cytometry showed the highest cartilage viability percentage in the fascia (Group F) and the lowest in the ADM (Group A). No significant difference was found in viability percentages between the groups. Histopathological examinations supported the flow cytometry findings.
CONCLUSION: Our study revealed that cartilage grafts wrapped in allogenic fascia (Group F) showed better viability and stability compared with ADM (Group A) and bovine pericardium (Group T). This suggests that while fascia may remain the gold standard, alternative biomaterials also hold potential. Further experimental and clinical studies with larger sample sizes are needed to support these findings.
LEVEL OF EVIDENCE I: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
PMID:40021504 | DOI:10.1007/s00266-025-04770-7
Transseptal approach for pseudoaneurysms at the aortic root in Loeys-Dietz syndrome
Interdiscip Cardiovasc Thorac Surg. 2025 Feb 5;40(2):ivaf016. doi: 10.1093/icvts/ivaf016.
ABSTRACT
Loeys-Dietz syndrome involves vascular abnormalities and aortic root aneurysms. This study described a 10-year-old boy who presented with progressively enlarging ascending aortic aneurysm and mild aortic valve regurgitation. He was diagnosed with Loeys-Dietz syndrome and underwent aortic valve-sparing repair. However, 6 months after the surgery, aortic root pseudoaneurysms were detected. Thus, aortic root repair was performed by transseptal approach. The orifices of pseudoaneurysms were closed with double-layer patches composed of autologous and bovine pericardial patches. Based on the findings of this study, we conclude that the transseptal approach is useful for closing aneurysms at the aortic root.
PMID:39918975 | PMC:PMC11997791 | DOI:10.1093/icvts/ivaf016