Category: General

Kyobu Geka. 2025 Aug;78(8):626-629.

ABSTRACT

Cardiac herniation is a rare complication after pulmonary surgery. A 59-year-old woman underwent right-sided pneumonectomy for right pulmonary squamous cell carcinoma, pulmonary vein was ligated intrapericardialy and the pericardial defect, which mesasured about 2 cm was not repaired. After four months, the patient complained of bilateral lower leg edema and dyspnea on effort. Computed tomography (CT) showed the right atrial herniation into the right-sided thoracic cavity. We diagnosed with symptomatic cardiac herniation and performed opration with small thoracotomy. At operation it was found that the right atrium herniated into the right-sided thoracic cavity. There were no adhesions between the pericardium and the right atrium. We placed the right atrium back within the pericardium and repaired using a bovine pericardial patch. The postoperative course was uneventful. Bilateral lower leg edema and cardiac herniation disappeared. Cardiac herniation did not recur over four years postoperatively.

PMID:40840886

Adv Mater. 2025 Aug 5:e2504765. doi: 10.1002/adma.202504765. Online ahead of print.

ABSTRACT

Cardiac patches to repair myocardial defects require mechanically stable materials that prevent bleeding and can be implanted via suturing. The current clinical standard, bovine pericardial patches (BPPs), serve this purpose but do not degrade or integrate with the myocardium, limiting their long-term effectiveness. Here, we present the reinforced cardiac tissue patch (RCPatch). This multimaterial patch comprises a stiffness-tuned, cardiomyocyte-infiltrated 3D metamaterial and a suturable, hydrogel-infiltrated mesh to reduce permeability and bleeding. Anisotropic metamaterials are designed and computationally optimized using a generative modeling approach and fabricated from poly(ε-caprolactone) (PCL) via volumetric 3D printing (VP). The metamaterial supports the infiltration of cardiomyocytes, which are viable and contract in vitro. The implantability and low blood permeability of the patch is enabled by adding a melt-electrowritten (MEW) mesh infiltrated with a fibrin hydrogel. In an acute large animal trial, the RCPatch was applied on an induced myocardial defect, where it withstood intraventricular blood pressure, prevented bleeding, and enabled hemodynamic restabilization (intraventricular pressure of 81 mmHg before, vs 66 mmHg after implantation). These findings establish a scalable framework for fabricating cardiac tissue patches that integrate mechanical reinforcement with biological function, offering a surgically implantable and future regenerative solution for intraventricular myocardial repair.

PMID:40761175 | DOI:10.1002/adma.202504765

Plast Reconstr Surg Glob Open. 2025 Jul 1;13(7):e6941. doi: 10.1097/GOX.0000000000006941. eCollection 2025 Jul.

ABSTRACT

Red breast syndrome (RBS) is a rare and intriguing clinical phenomenon that remains only partially understood. It is characterized by erythema and warmth of the breast following breast reconstructive surgery. This clinical condition is typically associated with the use of acellular dermal matrix (ADM) over breast implants. Currently, surgeons prefer using ADMs for immediate prepectoral implant-based breast reconstruction to enhance aesthetic outcomes and promote better implant integration. ADMs can induce a local inflammatory response that may mimic an actual implant infection. Although rare, the etiology, diagnosis, and treatment of RBS present a significant challenge for both patients and healthcare professionals due to its enigmatic nature. We present a case of bilateral RBS following bilateral nipple-sparing mastectomy and immediate prepectoral implant-based breast reconstruction using a specific acellular collagen matrix derived from bovine pericardium. We detail our diagnostic approach and treatment strategy, which successfully resolved the syndrome while preserving both the breast implants and the ADMs.

PMID:40606802 | PMC:PMC12212803 | DOI:10.1097/GOX.0000000000006941