Off-pump coronary artery bypass grafting (CABG) remains technically demanding, especially in low-income settings. Understanding the surgical learning curve is crucial for optimizing outcomes, training, and res… Read More
Month: October 2025
Migration of Hem-O-Lok clip into the bronchus after video-assisted thoracoscopic surgery accompanied by Pseudomonas aeruginosa: a case report
The Hem-O-Lok clip is frequently used as a surgical consumable for the occlusion of blood vessels and bronchi during Video-Assisted Thoracoscopic Surgery (VATS). However, there is limited available literature … Read More
Long-Term Safety and Performance of a National Pericardium Organic Valvular Bioprosthesis in the Brazilian Public Health System: Retrospective Analysis Up To 26 Years of Follow-up
Braz J Cardiovasc Surg. 2025 Aug 26;40(5):e20240405. doi: 10.21470/1678-9741-2024-0405.
ABSTRACT
OBJECTIVE: To evaluate the long-term performance of a bovine pericardium valve prosthesis in individuals who required valve replacement in the Brazilian public health system.
METHODS: Medical records of patients having mitral or aortic valve replacement with bovine pericardium valve prostheses between 1978 and 1994 at a Brazilian hospital were reviewed in this retrospective study. Safety was assessed through the complications and serious adverse events rates in the early and long terms. Successful valve replacement was defined by absence of complications and serious adverse events up to 30 days after surgery.
RESULTS: A total of 439 surgeries were performed in 382 patients with a mean age of 46.45 ± 13.93 years. Mean follow-up time was 6.26 years (up to 26.13 years). Rheumatic etiology was present in 83.5% of the cases. Mitral valve replacement was the most performed surgery. Five complications in five patients were recorded up to 30 days after surgery, and the rate of serious adverse events for the same period was 10.3%. Successful valve replacement rate was 90.7%. Postoperative complications were reported during the follow-up period in 29.6% of the procedures, being calcification the most common with 17.3%.
CONCLUSIONS: Despite the young age of the patients, safety outcomes were in accordance with what is reported in the literature for bioprostheses, with acceptable complication, serious adverse events, and freedom from reintervention rates.
PMID:40857581 | PMC:PMC12400614 | DOI:10.21470/1678-9741-2024-0405
Rare advanced complication of an infusion port with pocket skin necrosis successfully preserve the port : a case report
The totally implantable venous access port (TIVAP) is widely recommended for patients requiring chemotherapy, total parenteral nutrition, or long-term antibiotic therapy. Nevertheless, pocket skin necrosis, al… Read More
Man in his third decade with a giant coronary artery aneurysm
This case report details a rare instance of chronic rupture in a 27-year-old male with a giant coronary artery aneurysm (GCAA) in the mid-left anterior descending artery (mid-LAD). Presenting with 4-month chro… Read More
Complete surgical resection of cortisol secreting neuroendocrine thymic tumour: a case report
Neuroendocrine tumours of the thymus are extremely rare, with an estimated incidence of about 1 in 5 million people. Although data is limited, complete surgical resection remains the most significant prognosti… Read More
Clinical utility of a small diameter four-row stapler reload for large vessel transection in lung transplants
In lung transplantation, there are multiple factors that can contribute to the need for a left atrial cuff reconstruction. While donor and recipient anatomy are inherent considerations during the procedure, ot… Read More
The TATEGIRI technique: adaptation of a longitudinal aortotomy for totally endoscopic aortic valve replacement
Endoscopic aortic valve replacement (TE‑AVR) is hindered by restricted visualization and instrument maneuverability. We describe TATEGIRI (Japanese: “vertical cut”), a longitudinal aortotomy adapted for the en… Read More
Electrospun textiles from decellularized bovine pericardium and polyvinyl alcohol (PVA) supporting blood coagulation: innovative approach in biomaterials for research purposes
Front Bioeng Biotechnol. 2025 Aug 11;13:1539759. doi: 10.3389/fbioe.2025.1539759. eCollection 2025.
ABSTRACT
INTRODUCTION: Current hemostatic agents face several limitations, including reduced effectiveness in controlling massive bleeding or preventing thrombogenic events. Functional bleeding control could allow time for further treatment and decrease mortality rates. Using suitable hemostatic agents may improve surgical outcomes by eliminating avoidable complications. Among all the patches available on the market, nanofibrous materials offer several advantages, among which the possibility to be properly designed in order to meet specific requirements related to bioactivity and biodegradability. Different patch formulations to support blood clotting are characterized in the present study.
METHODS: The approach used is based on electrospun decellularized bovine pericardium (dECM) blended or layered with polyvinyl alcohol (PVA) and crosslinked by (3-Glycidyloxypropyl)trimethoxysilane (GPTMS). Scanning electron microscopy and energy-dispersive X-ray spectroscopy were used in order to characterize the scaffold’s morphology and chemical composition. Mechanical properties were evaluated using a tensile stress test, while wettability was measured using contact angle analysis. The electrospun textiles’ surface interaction with whole blood and platelet rich plasma (PRP) was also examined. Thromboelastography (TEG) and in vitro clotting assays were performed in order to evaluate the clot formation, while flow cytometry was used to verify platelet activation. Finally, in order to evaluate the biological response to the degradation by-products of the electrospun textiles, cell viability was characterized through an indirect toxicity test using primary normal human dermal fibroblast (NHDF) as experimental model.
RESULTS AND DISCUSSION: Overall, the nanofibers-based textiles, optimized through blending and layering of dECM and PVA, successfully support stable clots. These biomaterials represent a valuable starting point for future research aimed to nanofibers’functionalization according to the desired application.
PMID:40861851 | PMC:PMC12375924 | DOI:10.3389/fbioe.2025.1539759
Biomechanical comparison of intuity vs. perceval aortic bioprosthesis: apples & oranges or swings & roundabouts?
Rapid deployment (RD) and sutureless (SU) aortic valve replacement (AVR) are established strategies with proven benefits and ongoing evolution. In this study, we compare the clinical results and technical attr… Read More