Management of pulmonary atresia with ventricular septal defect and ductal-dependent pulmonary circulation (PA/VSD/PDA) varies according to pulmonary artery morphology and institutional surgical strategy. We ad… Read More
Month: July 2025
NSUN2 inhibits NCOA4 expression to alleviate ferroptosis and inflammation in sepsis-induced myocardial injury in a m5C manner
Sepsis-induced myocardial injury (SIMI) leads to high morbidity and mortality. The 5-methylcytosine (m5C) RNA methyltransferase NOL1/NOP2/SUN domain (NSUN)2 is a therapeutic target for many diseases. The purpose … Read More
Why are soft collagenous tissues so tough?
Sci Adv. 2025 Jun 20;11(25):eadw0808. doi: 10.1126/sciadv.adw0808. Epub 2025 Jun 18.
ABSTRACT
Bovine pericardium is the tissue of choice for replacing heart valves of human patients in minimally invasive surgery. The tissue has an extraordinarily high toughness of ~100 kilojoules per square meter. Here, we investigate the origin of the toughness through mechanical tests and microscopic observations. In the tissue, crimped, long, strong collagen fibers are embedded in a soft matrix. As a crack grows in the matrix, the fibers decrimp, reorient, slip, and bridge the crack. These microscopic processes enable the fibers to transmit high tension over a long distance. Using two types of experiments, we measure the bridging traction as a function of crack separation, σ(δ). The peak traction is σ0 ~ 60 megapascals. The maximum separation is δ0 ~ 6 millimeters, two to four orders of magnitude higher than that of hard tissues. Both the high traction and large separation of the bovine pericardium contribute to its high toughness.
PMID:40532007 | PMC:PMC12175909 | DOI:10.1126/sciadv.adw0808
The role of the modified Glasgow prognostic score in predicting postoperative mortality following open-heart surgery
The Modified Glasgow Prognostic Score is an inflammation-based index utilizing C-reactive protein and albumin levels. It has been investigated in various diseases such as cancer, heart failure, and myocardial … Read More
The role of the modified Glasgow prognostic score in predicting postoperative mortality following open-heart surgery
The Modified Glasgow Prognostic Score is an inflammation-based index utilizing C-reactive protein and albumin levels. It has been investigated in various diseases such as cancer, heart failure, and myocardial … Read More
The role of the modified Glasgow prognostic score in predicting postoperative mortality following open-heart surgery
The Modified Glasgow Prognostic Score is an inflammation-based index utilizing C-reactive protein and albumin levels. It has been investigated in various diseases such as cancer, heart failure, and myocardial … Read More
Managing the Giant: A Novel Approach in Orthotopic Heart Transplantation With Extreme Left Atrial Enlargement
Clin Case Rep. 2025 Jul 27;13(8):e70655. doi: 10.1002/ccr3.70655. eCollection 2025 Aug.
ABSTRACT
This case report highlights an innovative surgical approach in orthotopic heart transplantation (OHT) for a patient with the largest recorded giant left atrium, measuring a biplanar volume of 1906 mL. The patient, a 63-year-old man with severe heart failure and a history of mitral and aortic valve replacements, presented with atrial fibrillation, moderate systolic dysfunction, and severe cardiomegaly. Despite optimized medical therapy, his condition warranted heart transplantation. The procedure involved a novel surgical technique utilizing Teflon reinforcement and a bovine pericardial patch to reconstruct the significantly enlarged left atrium. Postoperative outcomes were favorable, with no rejection episodes and resolution of pulmonary symptoms. This report underscores the challenges of atrial size mismatch in OHT and the necessity for tailored surgical strategies to address extreme anatomical variations. The successful outcome exemplifies the potential of customized approaches in complex heart transplant cases.
PMID:40735707 | PMC:PMC12301168 | DOI:10.1002/ccr3.70655
Trends and advances in cardiac rehabilitation for congenital heart disease: a bibliometric analysis
Congenital heart disease (CHD) survivors often suffer from impaired health-related quality of life (HRQoL), requiring cardiac rehabilitation (CR) as an additional intervention. CR involves various modalities a… Read More
The role of the modified Glasgow prognostic score in predicting postoperative mortality following open-heart surgery
The Modified Glasgow Prognostic Score is an inflammation-based index utilizing C-reactive protein and albumin levels. It has been investigated in various diseases such as cancer, heart failure, and myocardial … Read More
Progression of tricuspid and pulmonary regurgitation following surgical repair of subarterial ventricular septal defect via different approaches: predictors and outcomes
Subarterial Ventricular Septal Defect (SVSD) accounts for 10–30% of all VSD cases in Asia, and surgical repair using approaches has not yet been well-defined. However, further investigation is necessary to und… Read More