Observation of bronchial anatomy and variation of the middle lobe of the right lung based on three-dimensional reconstruction of lung CT

To explore the anatomical types and variations of lung segments and subsegment bronchi based on CT 3D reconstruction technology, and to provide anatomical theoretical support for thoracic surgeons in terms of …  Read More

The importance of tissue science and valve design in relation to durability and hemodynamics of the DurAVR aortic heart valve

Front Cardiovasc Med. 2025 Feb 7;12:1512961. doi: 10.3389/fcvm.2025.1512961. eCollection 2025.

ABSTRACT

INTRODUCTION: Clinical evidence highlighting the efficacy and safety of transcatheter aortic valve replacement (TAVR) and the 2019 Food and Drug Administration (FDA) approval for TAVR in low-risk (younger) patients has created a demand for durable and long-lasting bioprosthetic heart valve (BHV) leaflet materials. Over the life of an implanted BHV mechanical stress, immunogenicity, calcification, and hemodynamic dysfunction lead to failure via structural valve deterioration (SVD). Consequently, the durability of the bioprosthetic materials selected for valve manufacture is of utmost importance.

TECHNOLOGY: The ADAPT™ tissue engineering process, an anti-calcification preparation that transforms xenograft tissue (bovine pericardium) into a durable valve bioscaffold, shows significant clinical benefits in mitigating the interrelated mechanisms leading to SVD. The novel acellular, biostable and non-calcifying biomaterial has recently been molded into a single-piece 3D biomimetic valve (DurAVR™) with excellent early clinical results and the potential to meet the growing demand of durable BHVs for the treatment of aortic stenosis.

DISCUSSION: The unique design of the DurAVR biomimetic valve in combination with the superior biostability of ADAPT tissue could advance the BHV space by providing superior performance and durability to aortic stenosis patients in need of TAVR.

PMID:39991635 | PMC:PMC11842446 | DOI:10.3389/fcvm.2025.1512961

Observation of bronchial anatomy and variation of the middle lobe of the right lung based on three-dimensional reconstruction of lung CT

To explore the anatomical types and variations of lung segments and subsegment bronchi based on CT 3D reconstruction technology, and to provide anatomical theoretical support for thoracic surgeons in terms of …  Read More

Real-time blood gas management: evaluating quantum perfusion system’s accuracy against a standard blood gas analysis in CPB

Continuous blood gas monitoring (CBGM) during cardiopulmonary bypass (CPB) is essential for maintaining optimal patient outcomes, enabling rapid responses to critical fluctuations in blood gas parameters. This…  Read More

LncRNA FAM66C predicts poor prognosis in patients with lung adenocarcinoma and regulates cell proliferation and metastasis via miR-339-3p

As one of the tumors with the highest fatality rates in the world, LUAD has a high risk of concealment, recurrence, and metastasis, which has turned into a significant issue in the medical community. To find p…  Read More

Observation of bronchial anatomy and variation of the middle lobe of the right lung based on three-dimensional reconstruction of lung CT

To explore the anatomical types and variations of lung segments and subsegment bronchi based on CT 3D reconstruction technology, and to provide anatomical theoretical support for thoracic surgeons in terms of …  Read More

The importance of tissue science and valve design in relation to durability and hemodynamics of the DurAVR aortic heart valve

Front Cardiovasc Med. 2025 Feb 7;12:1512961. doi: 10.3389/fcvm.2025.1512961. eCollection 2025.

ABSTRACT

INTRODUCTION: Clinical evidence highlighting the efficacy and safety of transcatheter aortic valve replacement (TAVR) and the 2019 Food and Drug Administration (FDA) approval for TAVR in low-risk (younger) patients has created a demand for durable and long-lasting bioprosthetic heart valve (BHV) leaflet materials. Over the life of an implanted BHV mechanical stress, immunogenicity, calcification, and hemodynamic dysfunction lead to failure via structural valve deterioration (SVD). Consequently, the durability of the bioprosthetic materials selected for valve manufacture is of utmost importance.

TECHNOLOGY: The ADAPT™ tissue engineering process, an anti-calcification preparation that transforms xenograft tissue (bovine pericardium) into a durable valve bioscaffold, shows significant clinical benefits in mitigating the interrelated mechanisms leading to SVD. The novel acellular, biostable and non-calcifying biomaterial has recently been molded into a single-piece 3D biomimetic valve (DurAVR™) with excellent early clinical results and the potential to meet the growing demand of durable BHVs for the treatment of aortic stenosis.

DISCUSSION: The unique design of the DurAVR biomimetic valve in combination with the superior biostability of ADAPT tissue could advance the BHV space by providing superior performance and durability to aortic stenosis patients in need of TAVR.

PMID:39991635 | PMC:PMC11842446 | DOI:10.3389/fcvm.2025.1512961