MicroRNAs (miRNAs) are closely related to cardiovascular diseases, including chronic heart failure (CHF). Endothelial dysfunction can lead to heart failure. The purpose of this study was to evaluate the clinic… Read More
Month: January 2025
Combined effects of reflexology massage and respiratory relaxation on pain following chest tube removal in heart surgery patients
Removing the chest tube in cardiac patients after surgery is one of the worst experiences of hospitalization in the intensive care units. Various pharmacological and non-pharmacological methods are available t… Read More
Left atrial appendage cannulation for left ventricular unloading in a patient with ventricular thrombus on extracorporeal life support
Left ventricular unloading is needed in patients on extracorporeal life support (ECLS) with severely impaired left ventricular contractility to avoid stasis and pulmonary congestion, and to promote LV recovery… Read More
Engineering of a bilayer antibacterial wound dressing from bovine pericardium and electrospun chitosan/PVA/antibiotics for infectious skin wounds management: An in vitro and in vivo study
Int J Biol Macromol. 2024 Dec;282(Pt 5):137055. doi: 10.1016/j.ijbiomac.2024.137055. Epub 2024 Nov 2.
ABSTRACT
Tissue deterioration and post-injury infections are the primary cause of skin diseases. Tissue engineering has developed various synthetic and natural polymers to generate bioactive scaffolds that can closely replicate the natural extracellular matrix (ECM). Decellularized tissues have emerged as a potential solution for reconstructing cutaneous lesions due to their ability to preserve the intricate protein structure and provide essential functional domains for cellular differentiation. In this study, we selected bovine pericardium and subjected it to diverse decellularization methods to optimize ECM preservation. Polyvinyl alcohol (PVA)/chitosan (CS) infused with two clinically important antibiotics (colistin and meropenem) was directly electrospun onto the decellularized bovine pericardium (DBPS) to endow the dual-layer scaffold (DBPS-Abs) an antibacterial property. Both DBPS-Abs and DBPS demonstrated a consistent 3D microstructure with interlinked pore networks, minimal degradation, and robust mechanical stability. The DBPS-Abs group exhibited a potent antibacterial effect against standard and clinical strains of Escherichia coli. Moreover, implanting the constructs into full-thickness skin wounds in mice confirmed enhanced wound regeneration in cases treated with DBPS-Abs compared to other groups, observed over a 7- and 21-day post-implantation period. These findings highlight DBPS-Abs as a superior antibacterial wound dressing, requiring further clinical evaluations.
PMID:39491709 | DOI:10.1016/j.ijbiomac.2024.137055
Anomalous drainage of lingular vein into left inferior pulmonary vein during thoracoscopic lung cancer surgery
The intricate anatomical variations in lung structure often perplex thoracic surgeons, and the accurate identification of these variations is closely associated with favorable surgical outcomes.
Aortic lumen repair with glue-felt technique before proximal anastomosis in acute type a aortic dissection surgery
Despite the advances in medicine, aortic dissection remains a cardiac surgery emergency with high mortality and morbidity rates. This study examined the effects of the Glue + Felt technique, which uses biologi… Read More
Correction to: Histological evaluation of decellularization of freeze dried and chemically treated indigenously prepared bovine pericardium membrane
Cell Tissue Bank. 2024 Dec;25(4):909. doi: 10.1007/s10561-024-10149-w.
NO ABSTRACT
PMID:39476272 | DOI:10.1007/s10561-024-10149-w
Combined simulation and ex vivo assessment of free-edge length in bicuspidization repair for congenital aortic valve disease
JTCVS Open. 2024 Sep 17;22:395-404. doi: 10.1016/j.xjon.2024.09.008. eCollection 2024 Dec.
ABSTRACT
OBJECTIVE: The study objective was to investigate the effect of free-edge length on valve performance in bicuspidization repair of congenitally diseased aortic valves.
METHODS: In addition to a constructed unicuspid aortic valve disease model, 3 representative groups-free-edge length to aortic diameter ratio 1.2, 1.57, and 1.8-were replicated in explanted porcine aortic roots (n = 3) by adjusting native free-edge length with bovine pericardium. Each group was run on a validated ex vivo univentricular system under physiological parameters for 20 cycles. All groups were tested within the same aortic root to minimize inter-root differences. Outcomes included transvalvular gradient, regurgitation fraction, and orifice area. Linear mixed effects model and pairwise comparisons were used to compare outcomes across groups.
RESULTS: The diseased control group had a mean transvalvular gradient of 28.3 ± 5.5 mm Hg, regurgitation fraction of 29.6% ± 8.0%, and orifice area of 1.03 ± 0.15 cm2. In ex vivo analysis, all repair groups had improved regurgitation and transvalvular gradient compared with the diseased control group (P < .001). Free-edge length to aortic diameter of 1.8 had the highest amount of regurgitation among the repair groups (P < .001) and 1.57 the least (P < .001). Free-edge length to aortic diameter of 1.57 also exhibited the lowest mean gradient (P < .001) and the largest orifice area (P < .001).
CONCLUSIONS: Free-edge length to aortic diameter ratio significantly impacts valve function in bicuspidization repair of congenitally diseased aortic valves. As the ratio departs from 1.57 in either direction, effective orifice area decreases and both transvalvular gradient and regurgitation fraction increase.
PMID:39780804 | PMC:PMC11704580 | DOI:10.1016/j.xjon.2024.09.008
Rapid growth of calcified amorphous tumor with mitral annulus calcification: a case report
Gen Thorac Cardiovasc Surg Cases. 2024 Aug 31;3(1):39. doi: 10.1186/s44215-024-00164-4.
ABSTRACT
BACKGROUND: Calcified amorphous tumor (CAT) of the heart is a rare, non-neoplastic cardiac mass with mitral valves and annuli being the most common sites. The presence of mitral annular calcification (MAC) is associated with an increased risk of stroke or other systemic embolisms. Here, we report a case of CAT showing rapid growth with MAC and investigate the link between the two.
CASE PRESENTATION: A 71-year-old man presented at our hospital with dyspnea and had been undergoing hemodialysis for 26 years for chronic glomerulonephritis. Transthoracic echocardiography (TTE) revealed moderate mitral stenosis with bulky MAC. Two months later, the patient developed progressive dyspnea, and follow-up TTE revealed a highly mobile mass (8 × 5 mm) attached to the left ventricular (LV) side of the posterior MAC. He underwent surgery because of congestive heart failure and a high risk of embolization. Surgical inspection revealed that the tumor was attached beneath the P3 segment of the mitral valve on the LV side and was removed. When removing the MAC, toothpaste-like contents drained from the encapsulated mass inside the MAC at the P3 segment, where the tumor was located. After reconstructing the posterior mitral annulus defect with a bovine pericardial patch, mitral valve replacement with a mechanical prosthesis, a maze procedure, and left appendage closure were performed. Histopathological examination revealed that the excised tumor contained fibrin and calcium deposits. The mass was diagnosed as a CAT.
CONCLUSIONS: CAT may be one of the causes of stroke induced by MAC. Routine follow-up echocardiography should be recommended for patients with MAC, especially those undergoing hemodialysis.
PMID:39517092 | PMC:PMC11533609 | DOI:10.1186/s44215-024-00164-4
Anomalous drainage of lingular vein into left inferior pulmonary vein during thoracoscopic lung cancer surgery
The intricate anatomical variations in lung structure often perplex thoracic surgeons, and the accurate identification of these variations is closely associated with favorable surgical outcomes.